IMMUNE CHECKPOINT INHIBITORS PLUS DEBULKING SURGERY FOR PATIENTS WITH METASTATIC RENAL CELL CARCINOMA: CLINICAL OUTCOMES AND IMMUNOLOGICAL CORRELATES OF A PROSPECTIVE PILOT TRIAL

Abstract Surgical removal of primary tumors reverses tumor-mediated immune suppression in pre-clinical models with metastatic disease.However, how cytoreductive surgery in the metastatic setting modulates the immune responses in patients, especially in the context of immune checkpoint therapy (ICT), is not understood.We report the first prospective

The research presented the tagged (aesthetic and expressive characteristics in the works of Jean Dubuffet), so the research objective was: to know the aesthetic and expressive characteristics in the works of (Jean Dubuffet), and the research included four chapters.The aim of the research, the limits of the research, and the definition of terms.The

ObjectivesWhile corticosteroids have been hypothesized to exert protective benefits in patients infected with SARS-CoV-2, data remain mixed.This study sought to investigate the outcomes of methylprednisone administration in an Italian cohort of hospitalized patients with confirmed SARS-CoV-2 infection.MethodsPatients with confirmatory testing for S

The one-dimensional analytical approach is developed to predict and analyze the acoustic attenuation performance of three-pass perforated tube muffler with perforated bulkhead(s) and validated by comparing the transmission loss results from one-dimensional analytical approach and finite element method.The one-dimensional analytical approach is then